Dr Karen Keeshan

  • Reader (Paul O'Gorman Leukaemia Research Centre)

telephone: 0141 3307280
email: Karen.Keeshan@glasgow.ac.uk
pronouns: She/her/hers

R313 Level 3 Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, College of Medical, Veterinary and Life Sciences, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1QH

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-7266-0890

Biography

Dr Karen Keeshan is a Reader in Leukaemia Research at the Paul O’Gorman Leukaemia Research Centre, in the Institute of Cancer Sciences, University of Glasgow.  

Dr Keeshan graduated with a B.Sc. in Biochemistry from the University College Cork, Ireland in 1998. She trained for a PhD degree under the joint supervision of Prof. Tom Cotter and Dr Sharon McKenna and graduated with a PhD on Apoptosis and Chronic Myeloid Leukaemia from University College Cork in 2002.  

Dr Keeshan carried out her postdoctoral training in the USA. She first undertook a post-doctoral research post in Prof. Bruno Calabretta’s laboratory in the Kimmel Cancer Centre, at Thomas Jefferson University, Philadelphia, working on signalling in Chronic Myeloid Leukaemia. She then undertook a second post-doctoral position in Prof. Warren Pear’s laboratory at the University of Pennsylvania. She held two Leukaemia and Lymphoma Society awards, The Leukemia and Lymphoma Society, Special Fellowship Award and The Leukemia and Lymphoma Society, Career Development Award working on Acute Lymphoid and Acute Myeloid leukaemia where she first identified TRIB2 as a novel oncogene.   

In 2008, Dr Keeshan was awarded a President of Ireland Young Researcher award (PIYRA) a highly prestigious award granted by the President of Ireland on behalf of the Irish Government Agency Science Foundation Ireland which supports “future leaders”. She also received a Marie Sklodowska-Curie Actions –Individual Fellowship. These enabled Dr Keeshan to establish her Leukaemia research group at the University College Cork, Ireland.  

In 2012, Dr Keeshan moved her research group to the University of Glasgow having been awarded a non clinical Senior Lecturer post in Paediatric Haematology funded by the Howat Foundation and Children with Cancer UK, to develop paediatric leukaemia research in Scotland. She has received additional funding from Blood Cancer UK, Yorkhill Leukaemia & Cancer Research Fund and a number of additional charity, studentship and grant awards. Dr Keeshan reviews for high impact journals, a large number of funding agencies including charities and government, is a panel evaluator for fellowships including Marie Sklodowska-Curie Actions and enjoys collaborating with colleagues across the world, giving seminars and talks at international conferences and institutes. Dr Keeshan is a leader in Tribbles and cancer research, and has co-organised international conferences in this field.  

Dr Keeshan was promoted to Reader in Leukaemia Research in 2016 at the University of Glasgow. She works closely with clinical colleagues at the Royal Hospital for Children and has trained clinical and non-clinical researchers in Leukaemia Research aiming to translate our scientific advances in paediatric leukaemia into clinical practice. Research in the lab focuses on acute myeloid leukaemia and identifying paediatric disease specifications that may improve current therapy. PhD students and post-doctoral researchers in Dr Keeshan’s group are offered opportunities to attend local, national and international conferences and have been awarded prices for selected talks and travel awards. Lab alumni have gone into a variety of careers including academic research, teaching, industry and clinical posts. 

Research interests

Research groups

Publications

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Number of items: 74.

2024

Laing, A. et al. (2024) Paediatric bone marrow mesenchymal stem cells support acute myeloid leukaemia cell survival and enhance chemoresistance via contact-independent mechanism. British Journal of Haematology, (doi: 10.1111/bjh.19884) (Early Online Publication)

Mardilovich, Katerina, Naylor, Gregory, Julian, Linda, Phinichkusolchit, Narisa, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Blyth, Karen ORCID logoORCID: https://orcid.org/0000-0002-9304-439X and Olson, Michael F. ORCID logoORCID: https://orcid.org/0000-0003-3428-3507 (2024) Caspase-resistant ROCK1 expression prolongs survival of Eµ-Myc B cell lymphoma mice. Disease Models and Mechanisms, 17(5), dmm050631. (doi: 10.1242/dmm.050631) (PMID:38616733) (PMCID:PMC11139034)

2023

Stavrou, V. et al. (2023) Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment. Cancer Immunology, Immunotherapy, 72(3), pp. 543-560. (doi: 10.1007/s00262-022-03268-4) (PMID:35962843) (PMCID:PMC9947083)

2022

Jamieson, Sam A., Pudjihartono, Michael, Horne, Christopher R., Viloria, Juan Salamanca, Dunlop, Jessica L., McMillan, Hamish D., Day, Robert C., Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Murphy, James M. and Mace, Peter D. (2022) Nanobodies identity an activated state of the TRIB2 pseudokinase. Structure, 30(11), 1518-1529.e5. (doi: 10.1016/j.str.2022.08.006) (PMID:36108635)

Pirillo, C. et al. (2022) Metalloproteinase inhibition reduces AML growth, prevents stem cell loss and improves chemotherapy effectiveness. Blood Advances, 6(10), pp. 3126-3141. (doi: 10.1182/bloodadvances.2021004321) (PMID:35157757) (PMCID:PMC9131921)

Lal, Ridhima, Ritchie, Jake, Richmond, Laura ORCID logoORCID: https://orcid.org/0000-0002-8514-7030 and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2022) Detecting endogenous TRIB2 protein expression by flow cytometry and western blotting. In: Pseudokinases. Series: Methods in enzymology (667). Academic Press, pp. 59-77. ISBN 9780323915427 (doi: 10.1016/bs.mie.2022.03.024)

2021

Aung, Myint Myat Khine, Mills, Megan L., Bittencourt-Silvestre, Joana and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2021) Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia. Molecular Oncology, 15(9), pp. 2253-2272. (doi: 10.1002/1878-0261.12899) (PMID:33421304) (PMCID:PMC8410545)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12, 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2021) Superenhancing AML with Trib1. Blood, 137(1), pp. 8-9. (doi: 10.1182/blood.2020008315) (PMID:33410899)

Marensi, Vanessa, Keeshan, Karen R. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 and MacEwan, David J. (2021) Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors. Biochemical Pharmacology, 183, 114348. (doi: 10.1016/j.bcp.2020.114348) (PMID:33242449)

McMillan, Hamish D, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Dunbier, Anita K and Mace, Peter D (2021) Structure vs. Function of TRIB1—Myeloid Neoplasms and Beyond. Cancers, 13(12), 3060. (doi: 10.3390/cancers13123060) (PMID:34205360) (PMCID:PMC8235551)

2020

Richmond, Laura ORCID logoORCID: https://orcid.org/0000-0002-8514-7030 and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2020) Pseudokinases: a tribble‐edged sword. FEBS Journal, 287(19), pp. 4170-4182. (doi: 10.1111/febs.15096) (PMID:31621188)

Mitxitorena, Izaskun, Somma, Domenico ORCID logoORCID: https://orcid.org/0000-0003-2486-7250, Mitchell, Jennifer P., Lepistö, Matti, Tyrchan, Christian, Smith, Emma L., Kiely, Patrick A., Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 and Carmody, Ruaidhrí J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 (2020) The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits. Journal of Biological Chemistry, 295(33), pp. 11754-11763. (doi: 10.1074/jbc.RA120.014113) (PMID:32587091) (PMCID:PMC7450122)

Sarrou, Evgenia ORCID logoORCID: https://orcid.org/0000-0002-2777-4407, Richmond, Laura ORCID logoORCID: https://orcid.org/0000-0002-8514-7030, Carmody, Ruaidhrí J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507, Gibson, Brenda and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2020) CRISPR gene editing of murine blood stem and progenitor cells induces MLL-AF9 chromosomal translocation and MLL-AF9 leukaemogenesis. International Journal of Molecular Sciences, 21(12), 4266. (doi: 10.3390/ijms21124266) (PMID:32549410) (PMCID:PMC7352880)

2019

Collins, Patricia E., Somma, Domenico ORCID logoORCID: https://orcid.org/0000-0003-2486-7250, Kerrigan, David, Herrington, Felicity, Keeshan, Karen R. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Nibbs, Robert J.B. ORCID logoORCID: https://orcid.org/0000-0002-8150-0044 and Carmody, Ruaidhri J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 (2019) The IκB-protein BCL-3 controls toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus. Proceedings of the National Academy of Sciences of the United States of America, 116(51), pp. 25828-25838. (doi: 10.1073/pnas.1900408116) (PMID:31772019) (PMCID:PMC6926074)

Smith, Emma L., Somma, Domenico ORCID logoORCID: https://orcid.org/0000-0003-2486-7250, Kerrigan, David, McIntyre, Zoe, Cole, John J., Liang, Kai Ling, Kiely, Patrick A., Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 and Carmody, Ruaidhri J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80. Nucleic Acids Research, 47(21), pp. 11151-11161. (doi: 10.1093/nar/gkz873) (PMID:31598684) (PMCID:PMC6868378)

Mussai, F. et al. (2019) Targeting the arginine metabolic brake enhances immunotherapy for leukaemia. International Journal of Cancer, 145(8), pp. 2201-2208. (doi: 10.1002/ijc.32028) (PMID:30485425) (PMCID:PMC6767531)

2018

Chaudhury, S. et al. (2018) Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias. Nature Communications, 9, 5280. (doi: 10.1038/s41467-018-07584-1) (PMID:30538250) (PMCID:PMC6290074)

Salomé, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X, Hopcroft, Lisa ORCID logoORCID: https://orcid.org/0000-0002-7022-1322 and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2018) Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis. Experimental Hematology, 66, 63-78.e13. (doi: 10.1016/j.exphem.2018.07.005) (PMID:30031847)

Foulkes, D. M. et al. (2018) Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. Science Signaling, 11(549), eaat7951. (doi: 10.1126/scisignal.aat7951) (PMID:30254057) (PMCID:PMC6553640)

Newcombe, Ashley A., Gibson, Brenda E.S. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2018) Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia. Experimental Hematology, 63, pp. 1-11. (doi: 10.1016/j.exphem.2018.03.008) (PMID:29608923)

Salomé, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X, Magee, Aoife, Yalla, Krishna, Chaudhury, Shahzya ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Sarrou, Evgenia ORCID logoORCID: https://orcid.org/0000-0002-2777-4407, Carmody, Ruaidhri J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2018) A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling. Cell Death and Disease, 9(5), 443. (doi: 10.1038/s41419-018-0467-3) (PMID:29670085) (PMCID:PMC5906628)

O'Connor, Caitriona, Yalla, Krishna, Salome, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X, Moka, Hothri Ananyambica, Gómez Castañeda, Eduardo, Eyers, Patrick A. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2018) Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2. Oncotarget, 9(19), pp. 14977-14992. (doi: 10.18632/oncotarget.24525) (PMID:29599919) (PMCID:PMC5871090)

2017

Laing, Alison A., Harrison, Christine J., Gibson, Brenda E.S. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2017) Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia. Experimental Hematology, 54, pp. 40-50. (doi: 10.1016/j.exphem.2017.06.007) (PMID:28668350)

Sarrou, Evgenia ORCID logoORCID: https://orcid.org/0000-0002-2777-4407, Gibson, Brenda and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2017) Absence of Mcm6 mimics haemopoietic ageing and has implications for leukaemic transformation. 46th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, Frankfurt, Germany, 24-27 Aug 2017. S69. (doi: 10.1016/j.exphem.2017.06.134)

Carmody, Ruaidhri ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2017) The Tribble with APL: a new road to therapy. Cancer Cell, 31(5), pp. 612-613. (doi: 10.1016/j.ccell.2017.04.011) (PMID:28486101)

Eyers, Patrick A., Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 and Kannan, Natarajan (2017) Tribbles in the 21st Century: the evolving roles of Tribbles pseudokinases in biology and disease. Trends in Cell Biology, 27(4), pp. 284-298. (doi: 10.1016/j.tcb.2016.11.002) (PMID:27908682) (PMCID:PMC5382568)

Ahmed, Abrar, Wan, Xiaochun, Mitxitorena, Izaskun, Lindsay, Andrew J., Pandolfi, Pier Paolo, McCaffrey, Mary W., Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Chen, Youhai H. and Carmody, Ruaidhri J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 (2017) Regulation of NF-κB by PML and PML-RARα. Scientific Reports, 7, 44539. (doi: 10.1038/srep44539) (PMID:28317833) (PMCID:PMC5357907)

2016

Chaudhury, Shahzya S. ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Gibson, Brenda and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

O'Connor, C. et al. (2016) The presence of C/EBPα and its degradation are both required for TRIB2 mediated leukaemia. Oncogene, 35(40), pp. 5272-5281. (doi: 10.1038/onc.2016.66) (PMID:26996668)

Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Vieugué, Pauline, Chaudhury, Shahzya ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Rishi, Loveena, Gaillard, Coline, LIang, Lu, Garcia, Elaine, Nakumura, Takuro, Omidvar, Nader and Kogan, Scott C. (2016) Co-operative leukaemogenesis in acute myeloid leukaemia and acute promyelocytic leukaemia reveal C/EBPα as a common target of TRIB1 and PML/RARA. Haematologica, 101(10), pp. 1228-1236. (doi: 10.3324/haematol.2015.138503) (PMID:27390356) (PMCID:PMC5046652)

Liang, Kai Ling, Paredes, Roberto, Carmody, Ruaidhri ORCID logoORCID: https://orcid.org/0000-0002-9474-4507, Eyers, Patrick A., Meyer, Stefan, McCarthy, Tommie V. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) Human TRIB2 oscillates during the cell cycle and promotes ubiquitination and degradation of CDC25C. International Journal of Molecular Sciences, 17(9), 1378. (doi: 10.3390/ijms17091378) (PMID:27563873) (PMCID:PMC5037658)

Chaudhury, S. ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Gibson, B. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) The Impact of Cellular Age on Leukaemic Transformation. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016. p. 12.

Salomè, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) TRIB2 Regulates the Cell Cycle Under Stress Conditions in a Murine Cell Model of Leukaemia. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.

Sarrou, S., Gibson, B. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) Efficient Genome Editing of Mouse Hematopoietic Cells Using Crispr/Cas9 Technology. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2013. p. 295.

Yalla, Krishna, O'Connor, Caitriona, Campos, Joana and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) TRIB2 Transformed GMP is the Myeloid Leukaemia Initiating Cell. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.

Liang, Kai Ling, O'Connor, Caitriona, Veiga, J. Pedro, McCarthy, Tommie V. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) TRIB2 regulates normal and stress-induced thymocyte proliferation. Cell Discovery, 2, 15050. (doi: 10.1038/celldisc.2015.50) (PMID:27462446) (PMCID:PMC4860960)

2015

Latif, Anne-Louise, Cole, John J., Monteiro Campos, Joana, Clark, Willliam, McGarry, Lynn, Brock, Claire, Newcombe, Ashley, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X and Adams, Peter D. (2015) Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia. Blood, 126(23), p. 674. (doi: 10.1182/blood.V126.23.674.674)

Salome, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X, Campos, Joana and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2015) TRIB2 and the ubiquitin proteasome system in cancer. Biochemical Society Transactions, 43(5), pp. 1089-1094. (doi: 10.1042/bst20150103) (PMID:26517929)

Chaudhury, Shahzya S. ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Morison, Jessica K., Gibson, Brenda E.S. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2015) Insights into cell ontogeny, age and acute myeloid leukaemia. Experimental Hematology, 43(9), pp. 745-755. (doi: 10.1016/j.exphem.2015.05.008) (PMID:26051919)

Liang, Kai Ling, O'Connor, Caitriona, McCarthy, Tommie V. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2015) Investigation of the role of TRIB2 in normal murine hematopoiesis. Experimental Hematology, 43(9), S77. (doi: 10.1016/j.exphem.2015.06.181)

Pellicano, Francesca, O'Connor, Caitriona and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2015) An investigation of the leukaemia initiating cell in TRIB2 mediated AML. Experimental Hematology, 43(9), S88. (doi: 10.1016/j.exphem.2015.06.228)

O'Connor, Caitriona, Campos, Joana, Osinski, Jason M., Gronostajski, Richard M., Michie, Alison ORCID logoORCID: https://orcid.org/0000-0002-5404-475X and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2015) Nfix expression critically modulates early B lymphopoiesis and myelopoiesis. PLoS ONE, 10(3), e0120102. (doi: 10.1371/journal.pone.0120102) (PMID:25780920) (PMCID:PMC4363787)

2014

Lohan, Fiona, O'Connor, Caitriona, Campos, Joana, Ohlsson, Ewa, Salome, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X, Forde, Ciaran, Cahill, Mary, Kiely, Patrick, Porse, Bo and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2014) Targeting C/EBPalpha p42 and oncogene cooperativity in acute myeloid leukaemia. Experimental Hematology, 42(8), S42. (doi: 10.1016/j.exphem.2014.07.153)

O'Connor, Caitriona, Campos, Joana, Murphy, Brian, Hannon, Maura, Gronostajski, Richard, Michie, Alison ORCID logoORCID: https://orcid.org/0000-0002-5404-475X and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2014) NFIX influences stem and progenitor lineage fate. Experimental Hematology, 42(8), S54. (doi: 10.1016/j.exphem.2014.07.205)

Ni Ealaithe, C., Rishi, L. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2014) Analysis of Trib genes in leukaemia. Irish Journal of Medical Science, 183(S4), S133-S134. (doi: 10.1007/s11845-014-1153-9)

Rishi, L. et al. (2014) Regulation of Trib2 by an E2F1-C/EBP feedback loop in AML cell proliferation. Blood, 123(15), pp. 2389-2400. (doi: 10.1182/blood-2013-07-511683) (PMID:24516045)

Walsh, Sinéad, Gavin, Aisling, Wyatt, Séan, O'Connor, Catriona, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Nolan, Yvonne M., O'Keeffe, Gerard W. and Sullivan, Aideen M. (2014) Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease. International Journal of Neuroscience, 125(1), pp. 70-77. (doi: 10.3109/00207454.2014.904304)

2013

Lohan, F. et al. (2013) Elucidation and therapeutic targeting of the molecular mechanism of TRIB2-mediated acute myeloid leukaemia. Blood, 122(21), p. 3792.

Ryan, S.M., O’Keeffe, G.W., O'Connor, C., Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 and Nolan, Y.M. (2013) Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation. Brain, Behavior, and Immunity, 33, pp. 7-13. (doi: 10.1016/j.bbi.2013.03.005)

Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Hannon, Maura, Rishi, Loveena, Hasemann, Marie, Frank, Anne-Katrine, Timoney, Jennifer, O'Connor, Caitriona, Cahill, Mary and Porse, Bo (2013) E2F1 positively regulates Trib2 pseudokinase expression and proliferation in acute leukaemia. Experimental Hematology, 41(8), S50. (doi: 10.1016/j.exphem.2013.05.197)

Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, O'Connor, Caitriona, Campos, Joana, Murphy, Brian, Hannon, Maura and Michie, Alison ORCID logoORCID: https://orcid.org/0000-0002-5404-475X (2013) NFIX expression critically modulates early B lymphopoiesis and myelopoiesis. Experimental Hematology, 41(8), S68. (doi: 10.1016/j.exphem.2013.05.267)

Liang, K.L., Rishi, L. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2013) Tribbles in acute leukemia. Blood, 121(21), pp. 4265-4270. (doi: 10.1182/blood-2012-12-471300)

Lohan, F. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2013) The functionally diverse roles of tribbles. Biochemical Society Transactions, 41(4), pp. 1096-1100. (doi: 10.1042/BST20130105)

2012

Hannon, M., Lohan, F., Erbilgin, Y., Sayitoglu, M., O’Hagan, K., Mills, K., Ozbek, U. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2012) Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL. British Journal of Haematology, 158(5), pp. 626-634. (doi: 10.1111/j.1365-2141.2012.09222.x)

Lohan, F. M. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2012) Mechanism of Trib2 mediated degradation of C/EBP-ain acute myelogenous leukaemia. British Journal of Haematology, 157(S1), p. 57. (doi: 10.1111/j.1365-2141.2012.09071.x)

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2012) Elevated Trib2 with Notch1 activation in pediatric/adult T-ALL. In: British Society for Haematology 52nd Annual Scientific Meeting, Glasgow, 16-18 April 2012,

2011

Hannon, M., Al-Shahrour, F., Ebert, B. L. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2011) Regulation of Trib2 gene expression in normal and AML cells. British Journal of Haematology, 153(Supl 1), pp. 6-7. (doi: 10.1111/j.1365-2141.2011.08609.x)

The Trustees of the University Of Pennsylvania (2011) Diagnostic and Therapeutic Utility of Tribbles-2 in Human Cancers. .

2010

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2010) 643 Degradation of C/EBPalpha by Trib proteins correlates with Trib mediated acute myeloid leukemia. European Journal of Cancer Supplements, 8(5), pp. 162-163. (doi: 10.1016/S1359-6349(10)71443-9)

Dedhia, P.H., Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Uljon, S., Xu, L., Vega, M.E., Shestova, O., Zaks-Zilberman, M., Romany, C., Blacklow, S.C. and Pear, W.S. (2010) Differential ability of Tribbles family members to promote degradation of C/EBP and induce acute myelogenous leukemia. Blood, 116(8), pp. 1321-1328. (doi: 10.1182/blood-2009-07-229450)

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Bailis, W., Dedhia, P. H., Vega, M. E., Shestova, O., Xu, L., Toscano, K., Uljon, S. N., Blacklow, S. C. and Pear, W. S. (2010) Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood, 116(23), pp. 4948-4957. (doi: 10.1182/blood-2009-10-247361)

2008

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Shestova, O., Ussin, L. and Pear, W.S. (2008) Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia. Blood Cells, Molecules, and Diseases, 40(1), pp. 119-121. (doi: 10.1016/j.bcmd.2007.06.005)

2007

Wouters, B.J. et al. (2007) Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood, 110(10), pp. 3706-3714. (doi: 10.1182/blood-2007-02-073486)

2006

Chen, Y.-X., Yan, J., Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Tubbs, A.T., Wang, H., Silva, A., Brown, E.J., Hess, J.L., Pear, W.S. and Hua, X. (2006) The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proceedings of the National Academy of Sciences of the United States of America, 103(4), pp. 1018-1023. (doi: 10.1073/pnas.0510347103)

Ferrari-Amorotti, G., Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Zattoni, M., Guerzoni, C., Iotti, G., Cattelani, S., Donato, N.J. and Calabretta, B. (2006) Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBP. Blood, 108(4), pp. 1353-1362. (doi: 10.1182/blood-2006-01-011833)

Keeshan, K. et al. (2006) Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia. Cancer Cell, 10(5), pp. 401-411. (doi: 10.1016/j.ccr.2006.09.012)

Keeshan, K. et al. (2006) Tribbles homolog 2 (Trib2) inactivates C/EBPalpha and causes acute myelogenous leukemia. Blood, 108(11), p. 776.

Maillard, I., Tu, L., Sambandam, A., Yashiro-Ohtani, Y., Millholland, J., Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Shestova, O., Xu, L., Bhandoola, A. and Pear, W. S. (2006) The requirement for Notch signaling at the -selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. Journal of Experimental Medicine, 203(10), pp. 2239-2245. (doi: 10.1084/jem.20061020)

2003

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2003) Transcription activation function of C/EBP is required for induction of granulocytic differentiation. Blood, 102(4), pp. 1267-1275. (doi: 10.1182/blood-2003-02-0477)

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Cotter, T.G. and McKenna, S.L. (2003) Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1by a phosphoinositide-3-kinase (PI3K)-independent pathway. British Journal of Haematology, 123(1), pp. 34-44. (doi: 10.1046/j.1365-2141.2003.04538.x)

2002

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Cotter, T.G. and McKenna, S.L. (2002) High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion. Leukemia, 16(9), pp. 1725-34.

2001

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Mills, K.I., Cotter, T.G. and McKenna, S.L. (2001) Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype. Leukemia, 15(12), pp. 1823-1833.

2000

Di Bacco, Alessandra, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, McKenna, Sharon L. and Cotter, Thomas G. (2000) Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis. Oncologist, 5(5), pp. 405-415. (doi: 10.1634/theoncologist.5-5-405) (PMID:11040277)

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Number of items: 74.

Articles

Laing, A. et al. (2024) Paediatric bone marrow mesenchymal stem cells support acute myeloid leukaemia cell survival and enhance chemoresistance via contact-independent mechanism. British Journal of Haematology, (doi: 10.1111/bjh.19884) (Early Online Publication)

Mardilovich, Katerina, Naylor, Gregory, Julian, Linda, Phinichkusolchit, Narisa, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Blyth, Karen ORCID logoORCID: https://orcid.org/0000-0002-9304-439X and Olson, Michael F. ORCID logoORCID: https://orcid.org/0000-0003-3428-3507 (2024) Caspase-resistant ROCK1 expression prolongs survival of Eµ-Myc B cell lymphoma mice. Disease Models and Mechanisms, 17(5), dmm050631. (doi: 10.1242/dmm.050631) (PMID:38616733) (PMCID:PMC11139034)

Stavrou, V. et al. (2023) Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment. Cancer Immunology, Immunotherapy, 72(3), pp. 543-560. (doi: 10.1007/s00262-022-03268-4) (PMID:35962843) (PMCID:PMC9947083)

Jamieson, Sam A., Pudjihartono, Michael, Horne, Christopher R., Viloria, Juan Salamanca, Dunlop, Jessica L., McMillan, Hamish D., Day, Robert C., Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Murphy, James M. and Mace, Peter D. (2022) Nanobodies identity an activated state of the TRIB2 pseudokinase. Structure, 30(11), 1518-1529.e5. (doi: 10.1016/j.str.2022.08.006) (PMID:36108635)

Pirillo, C. et al. (2022) Metalloproteinase inhibition reduces AML growth, prevents stem cell loss and improves chemotherapy effectiveness. Blood Advances, 6(10), pp. 3126-3141. (doi: 10.1182/bloodadvances.2021004321) (PMID:35157757) (PMCID:PMC9131921)

Aung, Myint Myat Khine, Mills, Megan L., Bittencourt-Silvestre, Joana and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2021) Insights into the molecular profiles of adult and paediatric acute myeloid leukaemia. Molecular Oncology, 15(9), pp. 2253-2272. (doi: 10.1002/1878-0261.12899) (PMID:33421304) (PMCID:PMC8410545)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12, 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2021) Superenhancing AML with Trib1. Blood, 137(1), pp. 8-9. (doi: 10.1182/blood.2020008315) (PMID:33410899)

Marensi, Vanessa, Keeshan, Karen R. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 and MacEwan, David J. (2021) Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors. Biochemical Pharmacology, 183, 114348. (doi: 10.1016/j.bcp.2020.114348) (PMID:33242449)

McMillan, Hamish D, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Dunbier, Anita K and Mace, Peter D (2021) Structure vs. Function of TRIB1—Myeloid Neoplasms and Beyond. Cancers, 13(12), 3060. (doi: 10.3390/cancers13123060) (PMID:34205360) (PMCID:PMC8235551)

Richmond, Laura ORCID logoORCID: https://orcid.org/0000-0002-8514-7030 and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2020) Pseudokinases: a tribble‐edged sword. FEBS Journal, 287(19), pp. 4170-4182. (doi: 10.1111/febs.15096) (PMID:31621188)

Mitxitorena, Izaskun, Somma, Domenico ORCID logoORCID: https://orcid.org/0000-0003-2486-7250, Mitchell, Jennifer P., Lepistö, Matti, Tyrchan, Christian, Smith, Emma L., Kiely, Patrick A., Walden, Helen ORCID logoORCID: https://orcid.org/0000-0002-4289-4810, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 and Carmody, Ruaidhrí J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 (2020) The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits. Journal of Biological Chemistry, 295(33), pp. 11754-11763. (doi: 10.1074/jbc.RA120.014113) (PMID:32587091) (PMCID:PMC7450122)

Sarrou, Evgenia ORCID logoORCID: https://orcid.org/0000-0002-2777-4407, Richmond, Laura ORCID logoORCID: https://orcid.org/0000-0002-8514-7030, Carmody, Ruaidhrí J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507, Gibson, Brenda and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2020) CRISPR gene editing of murine blood stem and progenitor cells induces MLL-AF9 chromosomal translocation and MLL-AF9 leukaemogenesis. International Journal of Molecular Sciences, 21(12), 4266. (doi: 10.3390/ijms21124266) (PMID:32549410) (PMCID:PMC7352880)

Collins, Patricia E., Somma, Domenico ORCID logoORCID: https://orcid.org/0000-0003-2486-7250, Kerrigan, David, Herrington, Felicity, Keeshan, Karen R. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Nibbs, Robert J.B. ORCID logoORCID: https://orcid.org/0000-0002-8150-0044 and Carmody, Ruaidhri J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 (2019) The IκB-protein BCL-3 controls toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus. Proceedings of the National Academy of Sciences of the United States of America, 116(51), pp. 25828-25838. (doi: 10.1073/pnas.1900408116) (PMID:31772019) (PMCID:PMC6926074)

Smith, Emma L., Somma, Domenico ORCID logoORCID: https://orcid.org/0000-0003-2486-7250, Kerrigan, David, McIntyre, Zoe, Cole, John J., Liang, Kai Ling, Kiely, Patrick A., Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 and Carmody, Ruaidhri J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80. Nucleic Acids Research, 47(21), pp. 11151-11161. (doi: 10.1093/nar/gkz873) (PMID:31598684) (PMCID:PMC6868378)

Mussai, F. et al. (2019) Targeting the arginine metabolic brake enhances immunotherapy for leukaemia. International Journal of Cancer, 145(8), pp. 2201-2208. (doi: 10.1002/ijc.32028) (PMID:30485425) (PMCID:PMC6767531)

Chaudhury, S. et al. (2018) Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias. Nature Communications, 9, 5280. (doi: 10.1038/s41467-018-07584-1) (PMID:30538250) (PMCID:PMC6290074)

Salomé, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X, Hopcroft, Lisa ORCID logoORCID: https://orcid.org/0000-0002-7022-1322 and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2018) Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis. Experimental Hematology, 66, 63-78.e13. (doi: 10.1016/j.exphem.2018.07.005) (PMID:30031847)

Foulkes, D. M. et al. (2018) Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. Science Signaling, 11(549), eaat7951. (doi: 10.1126/scisignal.aat7951) (PMID:30254057) (PMCID:PMC6553640)

Newcombe, Ashley A., Gibson, Brenda E.S. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2018) Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia. Experimental Hematology, 63, pp. 1-11. (doi: 10.1016/j.exphem.2018.03.008) (PMID:29608923)

Salomé, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X, Magee, Aoife, Yalla, Krishna, Chaudhury, Shahzya ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Sarrou, Evgenia ORCID logoORCID: https://orcid.org/0000-0002-2777-4407, Carmody, Ruaidhri J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2018) A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling. Cell Death and Disease, 9(5), 443. (doi: 10.1038/s41419-018-0467-3) (PMID:29670085) (PMCID:PMC5906628)

O'Connor, Caitriona, Yalla, Krishna, Salome, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X, Moka, Hothri Ananyambica, Gómez Castañeda, Eduardo, Eyers, Patrick A. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2018) Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2. Oncotarget, 9(19), pp. 14977-14992. (doi: 10.18632/oncotarget.24525) (PMID:29599919) (PMCID:PMC5871090)

Laing, Alison A., Harrison, Christine J., Gibson, Brenda E.S. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2017) Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia. Experimental Hematology, 54, pp. 40-50. (doi: 10.1016/j.exphem.2017.06.007) (PMID:28668350)

Carmody, Ruaidhri ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2017) The Tribble with APL: a new road to therapy. Cancer Cell, 31(5), pp. 612-613. (doi: 10.1016/j.ccell.2017.04.011) (PMID:28486101)

Eyers, Patrick A., Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 and Kannan, Natarajan (2017) Tribbles in the 21st Century: the evolving roles of Tribbles pseudokinases in biology and disease. Trends in Cell Biology, 27(4), pp. 284-298. (doi: 10.1016/j.tcb.2016.11.002) (PMID:27908682) (PMCID:PMC5382568)

Ahmed, Abrar, Wan, Xiaochun, Mitxitorena, Izaskun, Lindsay, Andrew J., Pandolfi, Pier Paolo, McCaffrey, Mary W., Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Chen, Youhai H. and Carmody, Ruaidhri J. ORCID logoORCID: https://orcid.org/0000-0002-9474-4507 (2017) Regulation of NF-κB by PML and PML-RARα. Scientific Reports, 7, 44539. (doi: 10.1038/srep44539) (PMID:28317833) (PMCID:PMC5357907)

O'Connor, C. et al. (2016) The presence of C/EBPα and its degradation are both required for TRIB2 mediated leukaemia. Oncogene, 35(40), pp. 5272-5281. (doi: 10.1038/onc.2016.66) (PMID:26996668)

Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Vieugué, Pauline, Chaudhury, Shahzya ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Rishi, Loveena, Gaillard, Coline, LIang, Lu, Garcia, Elaine, Nakumura, Takuro, Omidvar, Nader and Kogan, Scott C. (2016) Co-operative leukaemogenesis in acute myeloid leukaemia and acute promyelocytic leukaemia reveal C/EBPα as a common target of TRIB1 and PML/RARA. Haematologica, 101(10), pp. 1228-1236. (doi: 10.3324/haematol.2015.138503) (PMID:27390356) (PMCID:PMC5046652)

Liang, Kai Ling, Paredes, Roberto, Carmody, Ruaidhri ORCID logoORCID: https://orcid.org/0000-0002-9474-4507, Eyers, Patrick A., Meyer, Stefan, McCarthy, Tommie V. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) Human TRIB2 oscillates during the cell cycle and promotes ubiquitination and degradation of CDC25C. International Journal of Molecular Sciences, 17(9), 1378. (doi: 10.3390/ijms17091378) (PMID:27563873) (PMCID:PMC5037658)

Liang, Kai Ling, O'Connor, Caitriona, Veiga, J. Pedro, McCarthy, Tommie V. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) TRIB2 regulates normal and stress-induced thymocyte proliferation. Cell Discovery, 2, 15050. (doi: 10.1038/celldisc.2015.50) (PMID:27462446) (PMCID:PMC4860960)

Latif, Anne-Louise, Cole, John J., Monteiro Campos, Joana, Clark, Willliam, McGarry, Lynn, Brock, Claire, Newcombe, Ashley, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X and Adams, Peter D. (2015) Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia. Blood, 126(23), p. 674. (doi: 10.1182/blood.V126.23.674.674)

Salome, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X, Campos, Joana and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2015) TRIB2 and the ubiquitin proteasome system in cancer. Biochemical Society Transactions, 43(5), pp. 1089-1094. (doi: 10.1042/bst20150103) (PMID:26517929)

Chaudhury, Shahzya S. ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Morison, Jessica K., Gibson, Brenda E.S. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2015) Insights into cell ontogeny, age and acute myeloid leukaemia. Experimental Hematology, 43(9), pp. 745-755. (doi: 10.1016/j.exphem.2015.05.008) (PMID:26051919)

Liang, Kai Ling, O'Connor, Caitriona, McCarthy, Tommie V. and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2015) Investigation of the role of TRIB2 in normal murine hematopoiesis. Experimental Hematology, 43(9), S77. (doi: 10.1016/j.exphem.2015.06.181)

Pellicano, Francesca, O'Connor, Caitriona and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2015) An investigation of the leukaemia initiating cell in TRIB2 mediated AML. Experimental Hematology, 43(9), S88. (doi: 10.1016/j.exphem.2015.06.228)

O'Connor, Caitriona, Campos, Joana, Osinski, Jason M., Gronostajski, Richard M., Michie, Alison ORCID logoORCID: https://orcid.org/0000-0002-5404-475X and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2015) Nfix expression critically modulates early B lymphopoiesis and myelopoiesis. PLoS ONE, 10(3), e0120102. (doi: 10.1371/journal.pone.0120102) (PMID:25780920) (PMCID:PMC4363787)

Lohan, Fiona, O'Connor, Caitriona, Campos, Joana, Ohlsson, Ewa, Salome, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X, Forde, Ciaran, Cahill, Mary, Kiely, Patrick, Porse, Bo and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2014) Targeting C/EBPalpha p42 and oncogene cooperativity in acute myeloid leukaemia. Experimental Hematology, 42(8), S42. (doi: 10.1016/j.exphem.2014.07.153)

O'Connor, Caitriona, Campos, Joana, Murphy, Brian, Hannon, Maura, Gronostajski, Richard, Michie, Alison ORCID logoORCID: https://orcid.org/0000-0002-5404-475X and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2014) NFIX influences stem and progenitor lineage fate. Experimental Hematology, 42(8), S54. (doi: 10.1016/j.exphem.2014.07.205)

Ni Ealaithe, C., Rishi, L. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2014) Analysis of Trib genes in leukaemia. Irish Journal of Medical Science, 183(S4), S133-S134. (doi: 10.1007/s11845-014-1153-9)

Rishi, L. et al. (2014) Regulation of Trib2 by an E2F1-C/EBP feedback loop in AML cell proliferation. Blood, 123(15), pp. 2389-2400. (doi: 10.1182/blood-2013-07-511683) (PMID:24516045)

Walsh, Sinéad, Gavin, Aisling, Wyatt, Séan, O'Connor, Catriona, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Nolan, Yvonne M., O'Keeffe, Gerard W. and Sullivan, Aideen M. (2014) Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease. International Journal of Neuroscience, 125(1), pp. 70-77. (doi: 10.3109/00207454.2014.904304)

Lohan, F. et al. (2013) Elucidation and therapeutic targeting of the molecular mechanism of TRIB2-mediated acute myeloid leukaemia. Blood, 122(21), p. 3792.

Ryan, S.M., O’Keeffe, G.W., O'Connor, C., Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 and Nolan, Y.M. (2013) Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation. Brain, Behavior, and Immunity, 33, pp. 7-13. (doi: 10.1016/j.bbi.2013.03.005)

Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Hannon, Maura, Rishi, Loveena, Hasemann, Marie, Frank, Anne-Katrine, Timoney, Jennifer, O'Connor, Caitriona, Cahill, Mary and Porse, Bo (2013) E2F1 positively regulates Trib2 pseudokinase expression and proliferation in acute leukaemia. Experimental Hematology, 41(8), S50. (doi: 10.1016/j.exphem.2013.05.197)

Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, O'Connor, Caitriona, Campos, Joana, Murphy, Brian, Hannon, Maura and Michie, Alison ORCID logoORCID: https://orcid.org/0000-0002-5404-475X (2013) NFIX expression critically modulates early B lymphopoiesis and myelopoiesis. Experimental Hematology, 41(8), S68. (doi: 10.1016/j.exphem.2013.05.267)

Liang, K.L., Rishi, L. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2013) Tribbles in acute leukemia. Blood, 121(21), pp. 4265-4270. (doi: 10.1182/blood-2012-12-471300)

Lohan, F. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2013) The functionally diverse roles of tribbles. Biochemical Society Transactions, 41(4), pp. 1096-1100. (doi: 10.1042/BST20130105)

Hannon, M., Lohan, F., Erbilgin, Y., Sayitoglu, M., O’Hagan, K., Mills, K., Ozbek, U. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2012) Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL. British Journal of Haematology, 158(5), pp. 626-634. (doi: 10.1111/j.1365-2141.2012.09222.x)

Lohan, F. M. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2012) Mechanism of Trib2 mediated degradation of C/EBP-ain acute myelogenous leukaemia. British Journal of Haematology, 157(S1), p. 57. (doi: 10.1111/j.1365-2141.2012.09071.x)

Hannon, M., Al-Shahrour, F., Ebert, B. L. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2011) Regulation of Trib2 gene expression in normal and AML cells. British Journal of Haematology, 153(Supl 1), pp. 6-7. (doi: 10.1111/j.1365-2141.2011.08609.x)

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2010) 643 Degradation of C/EBPalpha by Trib proteins correlates with Trib mediated acute myeloid leukemia. European Journal of Cancer Supplements, 8(5), pp. 162-163. (doi: 10.1016/S1359-6349(10)71443-9)

Dedhia, P.H., Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Uljon, S., Xu, L., Vega, M.E., Shestova, O., Zaks-Zilberman, M., Romany, C., Blacklow, S.C. and Pear, W.S. (2010) Differential ability of Tribbles family members to promote degradation of C/EBP and induce acute myelogenous leukemia. Blood, 116(8), pp. 1321-1328. (doi: 10.1182/blood-2009-07-229450)

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Bailis, W., Dedhia, P. H., Vega, M. E., Shestova, O., Xu, L., Toscano, K., Uljon, S. N., Blacklow, S. C. and Pear, W. S. (2010) Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood, 116(23), pp. 4948-4957. (doi: 10.1182/blood-2009-10-247361)

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Shestova, O., Ussin, L. and Pear, W.S. (2008) Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia. Blood Cells, Molecules, and Diseases, 40(1), pp. 119-121. (doi: 10.1016/j.bcmd.2007.06.005)

Wouters, B.J. et al. (2007) Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood, 110(10), pp. 3706-3714. (doi: 10.1182/blood-2007-02-073486)

Chen, Y.-X., Yan, J., Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Tubbs, A.T., Wang, H., Silva, A., Brown, E.J., Hess, J.L., Pear, W.S. and Hua, X. (2006) The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proceedings of the National Academy of Sciences of the United States of America, 103(4), pp. 1018-1023. (doi: 10.1073/pnas.0510347103)

Ferrari-Amorotti, G., Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Zattoni, M., Guerzoni, C., Iotti, G., Cattelani, S., Donato, N.J. and Calabretta, B. (2006) Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBP. Blood, 108(4), pp. 1353-1362. (doi: 10.1182/blood-2006-01-011833)

Keeshan, K. et al. (2006) Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia. Cancer Cell, 10(5), pp. 401-411. (doi: 10.1016/j.ccr.2006.09.012)

Keeshan, K. et al. (2006) Tribbles homolog 2 (Trib2) inactivates C/EBPalpha and causes acute myelogenous leukemia. Blood, 108(11), p. 776.

Maillard, I., Tu, L., Sambandam, A., Yashiro-Ohtani, Y., Millholland, J., Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Shestova, O., Xu, L., Bhandoola, A. and Pear, W. S. (2006) The requirement for Notch signaling at the -selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. Journal of Experimental Medicine, 203(10), pp. 2239-2245. (doi: 10.1084/jem.20061020)

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2003) Transcription activation function of C/EBP is required for induction of granulocytic differentiation. Blood, 102(4), pp. 1267-1275. (doi: 10.1182/blood-2003-02-0477)

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Cotter, T.G. and McKenna, S.L. (2003) Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1by a phosphoinositide-3-kinase (PI3K)-independent pathway. British Journal of Haematology, 123(1), pp. 34-44. (doi: 10.1046/j.1365-2141.2003.04538.x)

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Cotter, T.G. and McKenna, S.L. (2002) High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion. Leukemia, 16(9), pp. 1725-34.

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, Mills, K.I., Cotter, T.G. and McKenna, S.L. (2001) Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype. Leukemia, 15(12), pp. 1823-1833.

Di Bacco, Alessandra, Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890, McKenna, Sharon L. and Cotter, Thomas G. (2000) Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis. Oncologist, 5(5), pp. 405-415. (doi: 10.1634/theoncologist.5-5-405) (PMID:11040277)

Book Sections

Lal, Ridhima, Ritchie, Jake, Richmond, Laura ORCID logoORCID: https://orcid.org/0000-0002-8514-7030 and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2022) Detecting endogenous TRIB2 protein expression by flow cytometry and western blotting. In: Pseudokinases. Series: Methods in enzymology (667). Academic Press, pp. 59-77. ISBN 9780323915427 (doi: 10.1016/bs.mie.2022.03.024)

Conference or Workshop Item

Sarrou, Evgenia ORCID logoORCID: https://orcid.org/0000-0002-2777-4407, Gibson, Brenda and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2017) Absence of Mcm6 mimics haemopoietic ageing and has implications for leukaemic transformation. 46th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, Frankfurt, Germany, 24-27 Aug 2017. S69. (doi: 10.1016/j.exphem.2017.06.134)

Chaudhury, Shahzya S. ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Gibson, Brenda and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Chaudhury, S. ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Gibson, B. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) The Impact of Cellular Age on Leukaemic Transformation. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016. p. 12.

Salomè, Mara ORCID logoORCID: https://orcid.org/0000-0003-3267-650X and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) TRIB2 Regulates the Cell Cycle Under Stress Conditions in a Murine Cell Model of Leukaemia. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.

Sarrou, S., Gibson, B. and Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) Efficient Genome Editing of Mouse Hematopoietic Cells Using Crispr/Cas9 Technology. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2013. p. 295.

Yalla, Krishna, O'Connor, Caitriona, Campos, Joana and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) TRIB2 Transformed GMP is the Myeloid Leukaemia Initiating Cell. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.

Conference Proceedings

Keeshan, K. ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2012) Elevated Trib2 with Notch1 activation in pediatric/adult T-ALL. In: British Society for Haematology 52nd Annual Scientific Meeting, Glasgow, 16-18 April 2012,

Patents

The Trustees of the University Of Pennsylvania (2011) Diagnostic and Therapeutic Utility of Tribbles-2 in Human Cancers. .

This list was generated on Tue Jul 8 23:58:24 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Targeting leukaemia stems cells in childhood acute myeloid leukaemia
    Children with Cancer UK
    2025 - 2027
     
  • CD180 target validation in paediatric acute myeloid leukaemia
    Cancer Research UK
    2024 - 2025
     
  • Development of a novel SCLtTA/iMLL-AF9 murine model to investigate age-relevant disease biology in MLL-AF9 leukaemia
    Tenovus Scotland
    2023 - 2024
     
  • Using single cell transcriptomics to combat chemoresistance and disease relapse in paediatric acute myeloid leukaemia.
    Children's Cancer and Leukaemia Group
    2022 - 2025
     
  • The role of the Bone Marrow Microenvironment in Acute Myeloid Leukaemia (AML) Drug Resistance.
    NHS Greater Glasgow and Clyde Endowment Funds
    2021 - 2022
     
  • Targeting ERBB signalling in acute myeloid leukaemia
    Blood Cancer UK
    2019 - 2022
     
  • Investigation of CD33-targeted therapy in childhood acute myeloid leukaemia (AML)
    Glasgow Children`s Hospital Charity
    2016 - 2019
     
  • The influence of the microenvironment in paediatric AML
    Yorkhill Leukaemia & Cancer Research Fund
    2016 - 2018
     
  • Dissecting the function of Bcl-3 in NF-kappaB signaling in B cells
    Biotechnology and Biological Sciences Research Council
    2015 - 2018
     
  • The importance of stem cell ontogeny in paediatric and adult acute myeloid leukaemia
    Glasgow Children`s Hospital Charity
    2014 - 2016
     
  • Investigating leukaemic stem cell responses following CD33-targeted therapy and the implications for low and high risk paediatric AML groups
    Aila Coull Foundation
    2014 - 2015
     
  • Targeting Trib2 oncogenic signalling in normal and malignant stem cells.
    Blood Cancer UK
    2013 - 2016
     

Supervision

SUPERVISION

Dr Karen Keeshan supervises Postdoctoral researchers, clinical research fellows and PhD students from countries around the world including Ireland, UK, Greece, Italy, Saudi Arabia, Egypt, Malaysia, Portugal, India, China, Spain, Poland, Australia.  

Dr Karen Keeshan supervises Masters students (MSc, MRes and MSci) from different courses and Institutes e.g. Cancer Sciences, Immunology, Biomedical Sciences. 

The lab also hosts students for final year undergraduate projects, Erasmus internships, summer internships, and second level school experiences. 

 

 

Teaching

TEACHING

Dr Karen Keeshan teaches and assesses on a number of masters and medicine courses;

 

Course Lead on Level 4 Undergraduate Cancer module; module development, principal lecturer and examiner

MSc Cancer Research & Precision Oncology; Supervisor and assessor

MB ChB BSc Intercalated course; lecturer and examiner

MSc/MRes Biomedical Sciences; Supervisor and assessor

MSc Medical Genetics & Genomics; Supervisor and assessor

MRes Biomedical Sciences and Integrative Mammalian biology; supervisor and assessor

BSc Life Sciences; supervisor and assessor

BSc (Med Sci) Clinical Medicine cancer studies; supervisor and assessor

 

Dr Karen Keeshan is external and internal PhD Thesis examiner for students at Universities across the UK and EU.

 


Dr Karen Keeshan on Twitter

Paediatric and Adult Acute Myeloid Leukaemia